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Immune health is fundamental to overall wellness, influencing how the body defends itself against allergens, pathogens, and environmental stressors. In today’s world—where immune imbalances are increasingly linked to allergies, skin disorders, and respiratory concerns—there is growing demand for safe, natural solutions that help restore immune balance without overstimulating the system.
L-92® is a heat-treated, proprietary strain of Lactobacillus acidophilus developed by Asahi Group Foods, Japan. Unlike live probiotics, L-92® is a paraprobiotic, meaning its immune-modulating benefits are delivered through non-viable bacterial cells. This makes it remarkably stable, highly safe, and suitable across a wide range of applications—from supplements to functional foods.
Decades of research show that L-92® supports immune system modulation by shifting the immune response toward Th1 dominance, activating regulatory T cells (Treg), and suppressing excessive Th2-mediated reactions—key mechanisms involved in allergic conditions and skin inflammation.
L-92® has been extensively studied in both children and adults, with clinical trials demonstrating its effectiveness in managing atopic dermatitis, allergic rhinitis, and seasonal immune symptoms, while also improving markers of skin and respiratory health.
As a stable, well-researched, and GRAS-recognized ingredient, L-92® offers a modern, evidence-based approach to immune support. Whether addressing seasonal allergies, supporting skin integrity, or promoting immune balance in sensitive individuals, L-92® represents a next-generation solution grounded in science and safety.
mechanism of action
- L‑92® modulates immune balance by tipping the Th1/Th2 cytokine response toward Th1 and activating regulatory T cells (Treg) via MAPK and NOD-like receptor signaling pathways.
- It stimulates dendritic cells to produce IL‑12, reducing allergen-specific IgE production and promoting immune homeostasis.
- Animal and in vitro studies show that L‑92® activates plasmacytoid dendritic cells (pDCs) and enhances Th1 & Treg signaling, suppressing Th2-driven inflammation.
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Optimizes the Th1/Th2 balanceand relieves allergy symptoms.
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Activatesplasmacytoid dendritic cells(pDCs) and maintains immune function.
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Heat-sterilized, postbiotic L-92 has been clinically proven its efficacies.

APPLICATIONS
Clinically proven to alleviate symptoms of hay fever, perennial allergic rhinitis, and atopic dermatitis in both children and adults
In a 24-week randomized trial in young children (10 months–3 years) with AD and food allergies, L‑92® significantly reduced SCORAD index and lowered TARC and total IgE levels, suggesting improved disease management
An 8-week RCT with 180 healthy adults demonstrated improved upper respiratory symptoms and activation of pDCs, indicating enhanced antiviral defense. L‑92® may modulate the gut microbiome, suppressing harmful bacteria like Enterobacteriaceae and Clostridium while promoting gut health